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Better screening, healthier living and new treatments have all continued to help cut the annual number of cancer cases and deaths in the United States, a new report says.

The findings showed that new cancer cases and deaths from cancer have declined significantly for both men and women and for most racial/ethnic populations.

These decreases were largely due to decreased incidence and death from lung, prostate and colon cancer among men and a drop in two of the three leading cancers in women (breast and colon cancers). New diagnoses for all types of cancer in the United States declined almost 1 percent per year from 1999 to 2006 and cancer deaths dropped 1.6 percent per year from 2001 to 2006.

The report, which appears in the Dec. 7 online edition of Cancer, was compiled from data by the American Cancer Society, the U.S. Centers for Disease Control and Prevention, the U.S. National Cancer Institute and the North American Association of Central Cancer Registries.

“For me, when I see the downturn in some cancers it says we can actually address the cancer burden through a variety of efforts,” said report author Brenda K. Edwards, associate director of the Surveillance Research Program at the U.S. National Cancer Institute.

But the battle against cancer continues, she stressed. “We see the downturn in mortality, but we still have almost 1.5 million people with new cancer diagnoses in 2009. So, we still have a large number of people affected. For some of them, we have relatively effective treatments and for others not so.”

Edwards noted that for the cancers that have seen the biggest decreases, such as breast and colon cancer, effective screening methods probably explain the downward trend, although there are still too few people who take advantage of them.

Cancer rates are still higher for men than for women, but men had the biggest declines in new cases and death, the report showed.

This year’s report focused on trends in colorectal cancer. Colorectal cancer, the third most-diagnosed cancer in both men and women, is also the second-leading cause of cancer deaths in the United States. Overall, colon cancer rates are declining, but the decline is mostly among those over 65. Increasing numbers of cases in men and women under 50 is worrisome, the report noted.

Among both men and women, there were major declines in colorectal cancer cases from 1985 to 1995, minor increases from 1995 to 1998, and significant declines from 1998 to 2006. Since 1984, death rates also dropped, with accelerated rates of decline since 2002 for men and since 2001 for women.

In fact, from 1975 to 2000, cases of colorectal cancer fell 22 percent; 50 percent of which was most likely due to changes in lifestyle, and 50 percent to more people being screened.

In addition, deaths from colorectal cancer fell 26 percent during the same time; 9 percent of the drop came from lifestyle changes, 14 percent came from screening and 3 percent came from improved treatment, according to the report.

Going forward, if there were no changes in lifestyle, screening or treatment, there would be a 17 percent drop in colorectal cancer deaths from 2000 to 2020. However, if current trends remain the same, there will be a 36 percent drop in colorectal cancer deaths.

But, if more Americans adopted more healthy lifestyles, such as quitting smoking, and were screened for colon cancer and had access to optimal treatment (such as more effective chemotherapy), deaths from colon cancer could be reduced by 50 percent by 2020, the report predicted.

Other highlights from the report were that among men, cases of prostate, lung, oral cavity, stomach, brain, colon and rectum cancers have declined, but cases of kidney/renal, liver and esophageal cancer, along with leukemia, myeloma and melanoma, are increasing.

Among women, cases of breast, colorectal, uterine, ovarian, cervical and oral cavity cancers decreased, but cases of lung, thyroid, pancreatic, bladder and kidney cancers, along with non-Hodgkin lymphoma, melanoma and leukemia are on the rise.

Where cancers have increased, Edwards noted that in most cases there are no effective screening tests to catch the cancer early. In addition, for many of these cancers, the causes aren’t known and there aren’t effective treatments, she said.

Cancer death rates remain highest among blacks and lowest among Asian/Pacific Islanders. Although death rates by race/ethnicity were similar for most cancers, deaths from pancreatic cancer, the fourth most common cause of cancer death in the United States, increased in white men and women but dropped among black men and women.

Among men, except for Asian/Pacific Islanders, the three leading causes of cancer death were lung, prostate and colorectal cancer. Among Asian/Pacific Islanders, lung, liver and colorectal cancers were the top three causes of cancer death.

For women, except Hispanic women, the three leading causes of cancer death were lung, breast and colorectal cancer. For Hispanic women, breast cancer was the leading cause of cancer deaths, the study authors noted.

These differences in death rates may be due to differences in risk behaviors, socioeconomic status and access to and use of screening and treatment, according to the report.

While these trends are expected to continue, they could be accelerated if more people would make the lifestyle changes needed to reduce their risk of cancer. These include not smoking, maintaining a healthy weight, eating a healthful diet and exercising.

In addition, lives could be saved if more people were screened for cancers such as breast and colon cancer, and if there was more access to newer treatments, the report said.

Dr. David L. Katz, director of the Prevention Research Center at Yale University School of Medicine, said that “there is enormous detail in this comprehensive report, but the take-away message is as clear as it is compelling: the incidence and death toll from cancer are both steadily, if gradually, declining.”

If you’ve got a painful, swollen bump at the base of your big toe known as a bunion, you probably want to know what can be done for relief.

The American Podiatric Medical Association offers these possible options:
Apply a non-medicated bunion pad.
Wear comfortable shoes with plenty of room in the toes, and a low heel.
Apply an ice pack over the bunion when it becomes swollen, red or painful.
Tape up the foot to help keep the toe in position.
Take an anti-inflammatory medication to ease swelling and pain. Ask your podiatrist if you’re a candidate for a cortisone injection.
Use orthotic shoe inserts to help keep the feet in better alignment.

The spread of breast cancer cells from the main tumor to other parts of the body is controlled by a growth factor known as TGFb, which may prove a promising target for new drugs to prevent metastatic breast cancer, British researchers say.

Previous studies have shown that TGFb (transforming growth factor beta) regulates normal cell growth and movement. In this new study, a team from Cancer Research UK used an advanced microscopy and analysis technique to document the movement of cancer cells from primary breast tumor sites in mice.

The researchers found that single breast cancer cells broke away from the main tumor and entered the blood system when TGFb turned on messenger genes in the cancer cells and then turned them off.

When TGFb was inactive, clumps (but not single cells) of breast cancer cells broke away from the main tumor. Because these clumps can spread only through the lymphatic system, not through the blood, the spread of cancer was local, the study authors explained.

“The results helped us to find the set of genes that are behind the spread of breast cancer — and that the genes need to be first turned on and then off in order for single cancer cells to be able to ‘relocate,’” study author Erik Sahai said in a news release from Cancer Research UK.

He noted that in “a medium-sized tumor there could be a billion cells — and only a small proportion might break away and spread. So it is like trying to find — and understand — a moving needle in a very big haystack.”

Measuring body mass index or waist size in overweight people can accurately predict the risk of heart disease, Dutch scientists said on Monday.

A large 10-year study found that half of all fatal heart disease cases and a quarter of all non-fatal cases are linked to being overweight and having a high body mass index (BMI) or large waist.

Body mass index and waist circumference are well known risk factors for cardiovascular diseases but the Dutch researchers said their work showed BMI and waist size could actually help predict the risk of dying from or developing heart disease.

“What this study shows is the substantial effect which (being) overweight and obesity have on cardiovascular disease, whether fatal of non-fatal,” said Ineke van Dis from the Netherlands Heart Foundation, who led the study.

“In the near future the impact of obesity on the burden of heart disease will be even greater.”

Dis and colleagues at the monitoring project on risk factors for chronic diseases at the Dutch National Institute for Public Health and the Environment measured between both BMI and waist circumference in 20,500 men and women 1993 and 1997.

When age-adjusted BMI and waist sizes were correlated with hospital records and cause-of-death data over 10 years, more than half (53 percent) of all fatal heart disease cases and around a quarter (25-30 percent) of all non-fatal cases were in people defined as overweight and obese.

Overweight people are defined as having a BMI of between 25 and 30 and obese people of 30 or more, according to the World Health Organization (WHO). BMI is calculated by dividing weight in kilograms by height in meters squared.

Waist circumference measurements in men were defined as between 94 and 101.9 cm for overweight and more than 102 cm for obese. In women these measurements were 80-87.9 cm for overweight and more than 88 cm for obese.

Obesity is increasing throughout the world and is now recognized as a major global public health concern.

“These findings underline the need for policies and activities to prevent overweight in the general population,” Dis said in the study, which was published in the European Journal of Cardiovascular Prevention and Rehabilitation.